Welcome to the Town of Pamplico.  The Town of Pamplico is located in Florence County and the Pee Dee Region of SC, along S.C. 51.   We are conveniently situated approximately 30 minutes from the City of Florence and I-95/I20, 1 hour from Myrtle Beach, 2.5 hours from the SC mountains, 2 hours from Charleston, SC, and 1.5 hours from Santee, SC.  Incorporated in December 1916, the Town now has a population of 1226 citizens (2010 Census).  Once one of South Carolina's largest tobacco markets, especially during the 1950s and 1960s, Pamplico is now a quiet rural town that is home to one of the area's finest school districts, Florence County School District Two.  The Mayor and Council are striving to make Pamplico an even safer and attractive town for all current and future residents, as well as a business friendly municipality.   The Downtown Streetscape Project, pictured below, was completed in 2010 with grant assistance from the SC Commerce Department.